You do not have to make the plays at one turn; you may have put down some cards into sets already, of course. If your last two cards are two 7s, and you pick up a third 7, most people play that you can go out by making a set, without needing a final discard.
The winner collects points from all the other players. The winner bases their point total on the remaining cards in the other players’ hands, regardless of whether the cards make up completed combinations or not — which is a good reason to put down melds as soon as you get them.
The players put their cards face-up on the table and call out how many points they have left for the winner. You score the cards according to the following scale:
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2s through 10s get their face value, meaning that a 5 is worth 5 points.
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Jacks, queens, and kings receive 10 points apiece.
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Wild cards cost you 15 points each, if you are playing with them (jokers are usually wild cards, and can complete any set; meaning, the joker can be a substitute for any other card in the deck).
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Aces, in keeping with their lowly status during the game, charge you 1 point only.
Laying all your cards down in one turn is called going rummy, which doubles your score. Obviously, the availability of this bonus affects your decision to put down combinations earlier rather than later. If you think that you can claim this bonus, you may want to delay putting down your combinations.
The first player to score 100 points is the winner. For a longer game, you can play to 250 points.